Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity - 06/12/11
, Züleyha Akkan Çetinkaya a, Fatih Güzelbulut b, Hayrünnisa Sezikli c, Selvinaz Özkara d, Süleyman Coşgun b, Can Gönen b, Ayşe Oya Kurdaş Övünç b
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Summary |
Background and objectives |
It was shown that supplementation of vitamins C and E to therapy increased Helicobacter pylori eradication rate. In the present study, we aimed to evaluate whether supplementation of antioxidant vitamins to therapy increases H. pylori eradication rates in patients with chronic stress and low antioxidant capacity.
Methods |
This study included 120 patients who presented to gastroenterology outpatient clinic with H. pylori-positive nonulcer dyspepsia and low total antioxidant capacity. Patients in group A (n=80) were given lansoprazole (30mg, BID), amoxicillin (1000mg, BID), and clarithromycin (500mg, BID) for 14 days, as well as vitamin C (500mg, BID) and vitamin E (200 IU, BID) for 30 days. Patients in group B (n=40) were given lansoprazole (30mg, BID), amoxicillin (1000mg, BID), and clarithromycin (500mg, BID) for 14 days.
Results |
Total antioxidant capacity were lower than normal levels in all patients. One hundred and fifteen patients (77 in group A, 38 in group B) were analyzed with per protocol analysis. In group A, H. pylori eradication was achieved in 63.8% of the patients included in the intention to treat analysis and in 66.2% of the patients included in the per protocol analysis. In group B, H. pylori eradication was achieved in 42.5% of the patients included in the intention to treat analysis and in 44.7% of the patients included in the per protocol analysis. Eradication rates were significantly higher in group A than in group B (P<0.005).
Conclusions |
Supplementation with vitamins C and E increased H. pylori eradication rate of standard triple therapy.
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Vol 35 - N° 11
P. 745-749 - novembre 2011 Retour au numéro
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