Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability - 30/11/11
Doi : 10.1016/j.jaci.2011.09.010
Laura Passerini, PhD a, Sven Olek, PhD b, Sara Di Nunzio, PhD a, Federica Barzaghi, MD a, Sophie Hambleton, MD c, Mario Abinun, MD c, Alberto Tommasini, MD d, Silvia Vignola, MD e, Marco Cipolli, MD f, Mario Amendola, PhD a, Luigi Naldini, MD a, g, Luisa Guidi, MD h, Massimiliano Cecconi, BSc i, Maria G. Roncarolo, MD a, g, Rosa Bacchetta, MD a 
a San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
b Epiontis GmbH, Berlin, Germany
c Department of Paediatric Immunology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
d IRCCS Burlo Garofalo, Paediatric Immunology Laboratory, Trieste, Italy
e Paediatric Gastroenterology, G. Gaslini Hospital, Genoa, Italy
f Cystic Fybrosis Center, Verona, Italy
g Vita Salute San Raffaele University, Milan, Italy
h Unit of Internal Medicine and Gastroenterology, Complesso Integrato Columbus, Università Cattolica del Sacro Cuore, Rome, Italy
i Human Genetics Laboratories, Ospedale Galliera, Genoa, Italy
| Supported by the Italian Telethon foundation (grant Tele9A3, Tele10A4, and GGP07241 to R.B.). |
|
| Disclosure of potential conflict of interest: S. Olek is a shareholder and manager of Epiontis GmbH. S. Hambleton receives research support from the Medical Research Council UK. A. Tommasini and R. Bacchetta receive research support from the Telethon Foundation. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2011
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 128 - N° 6
P. 1376 - décembre 2011 Retour au numéro
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