Salivary cortisol levels and allergy in children: The ALADDIN birth cohort - 30/11/11
, Magnus Borres, MD, PhD b, c, Matteo Bottai, PhD d, e, Gunnar Lilja, MD, PhD a, Frank Lindblad, MD, PhD f, g, Göran Pershagen, MD, PhD d, Annika Scheynius, MD, PhD h, Jackie Swartz, MD i, Töres Theorell, MD, PhD g, Johan Alm, MD, PhD a
Corresponding author: Fredrik Stenius, MD, PhD, Department of Clinical Science and Education, Södersjukhuset, Sachsska Barnsjukhuset, Södersjukhuset AB, S-11883 Stockholm, Sweden.Abstract |
Background |
Pre- and postnatal stress have been related to allergy in children, but evidence from prospective studies is limited. Several environmental factors can influence the salivary cortisol level, which is used as a measure of activity of the hypothalamic-pituitary-adrenal axis.
Objective |
The aim of this study was to assess the association between salivary cortisol levels at 6 months of age and allergic manifestations during the first 2 years of life.
Methods |
Salivary samples for the analysis of cortisol level were collected at 6 months of age on 3 occasions during 1 day from 203 children. Blood samples were collected at 6, 12, and 24 months of age for analyses of specific IgE. Information on allergy-related symptoms was obtained by repeated examinations of the children. Generalized estimating equation statistics were used to calculate the overall risk for outcome measures.
Results |
The adjusted odds ratio for the relationship between morning cortisol level and IgE sensitization was 1.60 (95% CI, 1.22-2.10, P = .001) and for eczema it was 1.28 (95% CI, 1.03-1.59, P = .026). The odds ratio for afternoon cortisol level in relation to sensitization and eczema was 1.56 (95% CI, 1.26-1.94, P < .001) and 1.33 (95% CI, 1.12-1.58, P = .001), respectively, and for evening cortisol level it was 1.49 (95% CI, 1.22-1.83, P < .001) and 1.37 (95% CI, 1.18-1.59, P < .001). Salivary cortisol level in the evening was associated with food allergy.
Conclusion |
The association between salivary cortisol levels in infancy and allergic sensitization and allergic symptoms suggests a role of an altered hypothalamic-pituitary-adrenal axis in the etiological process of allergies.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, sensitization, salivary cortisol, children, stress
Abbreviations used : ALADDIN, HPA, OR
Plan
| This work was funded by the Swedish Research Council, the Swedish Research Council for Working Life and Social Research; the Centre for Allergy Research and the “Mjölkdroppen” Society, Karolinska Institutet; Phadia AB; the Stockholm County Council; the Swedish Asthma and Allergy Research Association; the Swedish Pediatric Allergy Society; the Swedish Society of Medicine; the Cancer and Allergy Fund; Consul ThC Bergh-, Ekhaga-, “Frimurare Barnhuset” in Stockholm; and the Gyllenberg, Hesselman, Samariten, and Vårdal foundations. |
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| Disclosure of potential conflict of interest: F. Lindblad has received research support from the Swedish Council for Working Life and Social Research. The rest of the authors have declared that they have no conflict of interest. |
Vol 128 - N° 6
P. 1335-1339 - décembre 2011 Retour au numéro
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