Antioxidant and renoprotective activities of Ficus racemosa Linn. stem bark: Bioactivity guided fractionation study - 26/11/11
Abstract |
Ethanolic extract of Ficus racemosa [FRE] was subjected to bioactivity guided fractionation by steady state and kinetic methods using nanosecond pulse radiolysis and stopped-flow spectrophotometer. HPLC fingerprinting and other antioxidant studies revealed that quantitative difference in FRE and its fractions were insignificant. Hence FRE was chosen for the evaluation of renoprotective study in mice using ischemia/reperfusion injury. Pretreatment of FRE (50 and 100mg/kg) restored the serum biomarkers and tissue antioxidant status to near normal levels, which were altered in ischemic group. Further, HPLC studies revealed that FRE contains gallic acid (6.18mg/g) as major constituent and it is responsible for observed beneficial effects.
Le texte complet de cet article est disponible en PDF.Keywords : Ficus racemosa, Nanosecond pulse radiolysis, Stopped-flow spectrophotometer, Ischemic reperfusion, Renoprotective, Gallic acid
Plan
Vol 1 - N° 4
P. 273-281 - octobre 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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