Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder - 27/11/07
, J. Sánchez b, J. Sanz c, S. Reig b, C. Benito d, I. Leal e, F. Sarramea e, R. Rebolledo c, T. Palomo c, M. Desco b
Corresponding author. Tel./fax: +34923291448.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 8 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objectives |
A study of N-acetyl-aspartate (NAA) can provide data of interest about cortical alterations in psychotic illnesses. Although a decreased NAA level in the cerebral cortex is a replicated finding in chronic schizophrenia, the data are less consistent for bipolar disease. On the other hand, it is likely that NAA values in schizophrenia may differ in men and women.
Methods |
We used proton magnetic resonance spectroscopy (1H MRS) to examine NAA levels in the prefrontal cortex in two groups of male patients, one with schizophrenia (n=11) and the other with bipolar disorder (n=13) of similar duration, and compared them to a sample of healthy control males (n=10). Additionally, we compared the degree of structural deviations from normal volumes of gray matter (GM) and cerebrospinal fluid (CSF) in the dorsolateral prefrontal cortex.
Results |
Compared to controls, schizophrenia and bipolar patients presented decreased NAA to creatine ratios, while only the schizophrenia group showed an increase in CSF in the dorsolateral prefrontal region. There were no differences in choline to creatine ratios among the groups.
Conclusions |
These data suggest that the decrease in NAA in the prefrontal region may be similar in schizophrenia and bipolar disorder, at least in the chronic state. However, cortical CSF may be markedly increased in schizophrenia patients.
Le texte complet de cet article est disponible en PDF.Keywords : Schizophrenia, Bipolar disorder, N-acetyl-aspartate, Spectroscopy, Prefrontal cortex
Plan
Vol 22 - N° 8
P. 505-512 - novembre 2007 Retour au numéro
Article précédent
- Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia
- Radovan Prikryl, Eva Ceskova, Tomas Kasparek, Hana Kucerova
- Switching to the bingeing/purging subtype of anorexia nervosa is frequently associated with suicidal attempts
- C. Foulon, J.D. Guelfi, A. Kipman, J. Adès, L. Romo, K. Houdeyer, S. Marquez, M.C. Mouren, F. Rouillon, P. Gorwood
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?