Impact of lung transplantation on serum lipids in COPD - 12/11/11
, Salman Hashmi a , Michael Eberlein b, c , Aldo Iacono a , Giora Netzer a, d , Andrew DeFilippis e , Reda E. Girgis b , Peter P. Toth f, g , Steven Scharf a , Steven Jones e 
Corresponding author. University of Maryland Physicians, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA. Tel.: +1 410 328 8141; fax: +1 410 328 0177.Summary |
Background |
Severe chronic obstructive pulmonary disease is associated with high HDL cholesterol (HDL-C). We sought to examine the effect of lung transplantation on lipid profiles in patients with COPD.
Methods |
We analyzed 101 lung transplant recipients in a retrospective cohort of patients from two centers in whom lipid values were available both before as well as after transplantation. Sixty-one subjects were transplanted for severe COPD (93% GOLD stage 4).
Results |
Eighty-nine percent of subjects with COPD exhibited a decline in HDL-C. Median decline for the COPD cohort was 25 mg/dL (IQR 12–38 mg/dL, p < 0.0001). Non-COPD subjects exhibited no significant changes in HDL-C. Other lipid changes in the COPD cohort included a rise in triglycerides of 70 mg/dL (IQR 35 to 140, p < 0.0001). Decreases in HDL-C levels were independent from the rise in triglyceride levels. Neither LDL-C nor non-HDL-C demonstrated significant changes. Subjects with greater increases in prednisone exposure post-transplant exhibited lesser declines in HDL-C. Compared with tacrolimus, cyclosporine had no effect on observed changes in HDL-C or triglycerides, but was associated with a greater median rise in LDL-C.
Conclusions |
In patients with COPD, lung transplantation results in reductions in the serum levels of HDL-C. These changes are not observed in patients undergoing lung transplantation for diagnoses other than COPD.
Le texte complet de cet article est disponible en PDF.Keywords : COPD, Cholesterol, Lipoproteins, Lung transplantation, HDL
Plan
Vol 105 - N° 12
P. 1961-1968 - décembre 2011 Retour au numéro
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