Dedifferentiated adamantinoma associated with fibrous dysplasia - 26/10/11
, H. Jaafoura b, M. Bouaziz c, M. Ouertatani a, L. Abid b, M.H. Meherzi a, M.F. Ladeb c, M. Mestiri a
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Summary |
A 21-year-old patient presented with an aggressive lesion of the left tibia associated to lymph nodes and lung metastasis. Histological examination revealed a high grade spindle cell sarcoma involving some areas of cytokeratine positive cells. Ultrastructural examination showed the presence of epithelial features in the sarcomatoid cells. The diagnosis of dedifferentiated spindle-celled adamantinoma was established. A second lesion of the right tibia was diagnosed as fibrous dysplasia. The patient had a leg amputation. He died 2 years later with multiple lung and bone metastases. The diagnosis of dedifferentiated adamantinoma should be considered when a clinician is confronted with a tibial biopsy of a “keratin-positive sarcoma”. The association with fibrous dysplasia in this case is discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Adamantinoma, Dedifferentiation, Fibrous dysplasia, Malignant transformation, Electron microscope
Plan
Vol 97 - N° 7
P. 770-775 - novembre 2011 Retour au numéro
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