Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to the site of infection - 14/10/11
Corresponding author. Tel.: +82 2 3010 3305; fax: +82 2 3010 6970.Summary |
Background |
The clinical manifestations of extrapulmonary tuberculosis (E-TB) vary according to site of disease, so we tested the hypothesis that IFN-γ producing T-cell responses also vary in parallel. Therefore we conducted a prospective, blinded, observational study to evaluate the diagnostic performance of blood T-SPOT.TB according to the various sites of E-TB.
Methods |
From April 2008 to August 2010, all patients with suspected E-TB were enrolled at a tertiary hospital in an intermediate TB-burden country. Final diagnosis in patients with suspected E-TB was classified by clinical category.
Results |
A total of 368 patients with suspected E-TB were enrolled; 196 (53%) were classified as having TB, including 119 (32%) with confirmed TB, 34 (9%) probable TB, and 43 (12%) possible TB; the remaining 172 (47%) were classified as not having TB. After excluding patients with possible TB, the T-SPOT.TB was more sensitive in patients with chronic forms of E-TB such as lymph node or osteoarticular TB (93%, 95% CI 83%–97%) than in patients with acute forms of E-TB such as TB meningitis or miliary TB (79%, 95% CI 66%–87%, P = 0.03).
Conclusions |
The diagnostic performance of the blood T-SPOT.TB differs among patients with various clinical manifestations of E-TB.
Le texte complet de cet article est disponible en PDF.Keywords : Tuberculosis, Diagnosis, T-SPOT.TB
Plan
 | This study was presented in part at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, 12–15 September 2010 (Poster session, abstract no. 3197) and the authors were made George McCracken Infectious Diseases Fellows. |
Vol 63 - N° 5
P. 362-369 - novembre 2011 Retour au numéro
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