The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose - 01/10/11

Doi : 10.1016/j.ajem.2010.10.032

Han Joon Kim, MD, PhD ^a, Sang Hoon Oh, MD ^a, Chun Song Youn, MD ^a, Jung Hee Wee, MD ^a, Ji Hoon Kim, MD ^a, Won Jung Jeong, MD ^a, Soo Hyun Kim, MD ^a, Seung Hee Jeong, MPH ^b, Kyu Nam Park, MD, PhD ^a,^{^⁎}
^a Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea
^b CMC Clinical Research Coordinating Center, Department of Preventive Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea

^⁎Corresponding author. Department of Emergency Medicine, Seoul St Mary's Hospital, Seoul, 137-701, Republic of Korea. Tel.: +82 2 2258 1987; fax: +82 2 2258 1997.

Abstract

Objectives

The aim of this study was to investigate the associative factors of rhabdomyolysis in patients with doxylamine overdose who had normal creatine phosphokinase levels at admission.

Methods

This study included 169 patients who visited the emergency department of a tertiary teaching hospital after doxylamine overdose between January 1, 1998, and March 31, 2009. Demographic information, clinical variables, and laboratory data were investigated for the associative factors of rhabdomyolysis.

Results

Thirty-five (21%) of the 169 patients developed rhabdomyolysis. Patients who developed rhabdomyolysis differed from those who did not in the amount of doxylamine ingested, sex, heart rate, initial value of serum creatinine, and alanine aminotransferase. In the multivariate regression analysis, the only reliable predictors of rhabdomyolysis were the amount of doxylamine ingested (P = .004) and heart rate (P < .001).

Conclusion

Observation and laboratory follow-up are required for patients with large reported ingestions or tachycardia on admission, even if their creatine phosphokinase levels were normal.

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Vol 29 - N° 8

P. 903-907 - octobre 2011 Retour au numéro

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The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose - 01/10/11

Abstract

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