Very low pandemic influenza A (H1N1) 2009 mortality associated with early neuraminidase inhibitor treatment in Japan: Analysis of 1000 hospitalized children - 18/09/11
, Masayoshi Shinjoh b, 1, Keiko Mitamura c, 1, Takao Takahashi b, 1
Corresponding author. Tel.: +81 45 221 8181; fax: +81 45 681 9665.Summary |
Objective |
There were many cases of pandemic influenza A (H1N1) 2009 (H1N1/09) in Japan during the 2009–2010 epidemic. They accounted for 16% of the total population (20.7 million/128 million), and 59% of the patients were children 15 years of age and under (12.2 million/20.7million). However, there were only 38 paediatric deaths. We analyzed the clinical manifestations and treatment of children hospitalized because of H1N1/09 infection in order to clarify the association between treatment with neuraminidase inhibitors and the low mortality rate.
Methods |
A retrospective chart review was performed on a total of 1000 paediatric inpatients.
Results |
The causes of the hospitalizations were respiratory complications in 651 cases (65.1%), neurological complications in 255 cases (25.5%) and other complications in 94 cases. Neuraminidase inhibitors, primarily oseltamivir, had been used to treat 984 (98.4%) of the 1000 patients, and in 88.9% of the patients, treatment with neuraminidase inhibitors was initiated within 48 h after the onset of illness. Only 12 (1.2%) of the 1000 patients underwent mechanical ventilation, and one patient died of H1N1/09 infection.
Conclusions |
Although a high proportion of the patients in this study had severe respiratory complications, the case fatality rate was only 0.1%. The low mortality rate of children due to the H1N1/09 epidemic in Japan was probably attributable to the universal implementation of early treatment with neuraminidase inhibitors.
Le texte complet de cet article est disponible en PDF.Keywords : Influenza, Pandemic influenza A (H1N1) 2009, Neuraminidase inhibitor, Mortality rate, Paediatric inpatients
Plan
Vol 63 - N° 4
P. 288-294 - octobre 2011 Retour au numéro
Article précédent
- Seroprevalence of antibodies to pandemic (H1N1) 2009 influenza virus among health care workers in two general hospitals after first outbreak in Kobe, Japan
- Takao Toyokawa, Tomimasa Sunagawa, Yuichiro Yahata, Takaaki Ohyama, Tomoko Kodama, Hiroshi Satoh, Kumi Ueno-Yamamoto, Satoru Arai, Kazuko Araki, Fumito Odaira, Yuuki Tsuchihashi, Hideaki Takahashi, Keiko Tanaka-Taya, Nobuhiko Okabe
- Pandemic (H1N1) 2009 virus infection: Persistent viral shedding after Oseltamivir treatment
- Sawan Kanchana, Supannakhon Kanchana, Charas Chuntrakul, Kumthorn Malathum, Slinporn Prachayangprecha, Yong Poovorawan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?