Comparison of local intravascular drug-delivery catheter systems - 12/09/11

Doi : 10.1016/0002-8703(95)90139-6

Peter Gonschior, MD ^⁎,^a, Clemens Pahl ^a, Tanya Y. Huehns, MRCP ^a,^{^{**
Dr. Huehns is supported by the Peel Medical Research Trust, London, U.K.}}, Florian Gerheuser, MD ^a, Aysel Erdemci, MD ^a, Katharina Larisch, MD ^a, Marc Dellian, MD ^b, Stefan Deil, MD ^a, Alwin-E. Goetz, MD ^c, Hans A. Lehr, MD, PhD ^d, Berthold Ho¨fling, MD ^a
^a Medical Department I, University of Munich, Munich, Germany
^b Institute of Surgical Research, University of Munich, Munich, Germany
^c Institute of Anesthesiology, Klinikum Grosshadern, University of Munich, Munich, Germany
^d Department of Pathology, University of Washington, Seattle, Wash., USA

^*Reprint requests: P. Gonschior, MD, University of Munich, Medical Dept I, Klinikum Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany.

Abstract

Systemic and local delivery on the photosensitive drug Photofrin polyporphyrin was investigated in normal porcine arteries (n = 192). A macroporous balloon and a novel needle injection catheter were used for local drug delivery and compared with systemic delivery. Fluorescence microscopy combined with digital image analysis was used to quantify the drug-related fluorescence. Systemic delivery showed a maximum in the intima at 4 hours. Application with the porous balloon revealed maximum indicator-related fluorescence intensity in the intima after 5 minutes; delivery with the needle injection catheter resulted in a several-fold enhanced maximum in adventitia after 30 minutes compared with the maximum achieved with either systemic injection or porous balloon application. After 21 days fluorescence was detectable in arteries treated with the new needle injection catheter. Local drug delivery is feasible with either system, but prolonged delivery was achieved only with the needle injection catheter.

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Supported by the Deutsche Forschungsgemeinschaft (grant 1076/1–2) and Friedrich Bauer Foundation, Germany (grant 58/94)

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Vol 130 - N° 6

P. 1174-1181 - décembre 1995 Retour au numéro

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Comparison of local intravascular drug-delivery catheter systems - 12/09/11

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