Methanol Half-Life During Ethanol Administration: Implications for Management of Methanol Poisoning - 12/09/11
Abstract |
Study objective: To determine the half-life of methanol in methanol-poisoned patients who are treated with ethanol but not with hemodialysis.
Design: Case series. Setting: University Hospital, University of Manitoba. Participants: Three methanol-poisoned patients treated with ethanol but not with hemodialysis and three similar patients identified by a literature review. Results: Plots of terminal concentration versus time data were inconsistent with zero-order kinetics and were adequately explained by an apparent first-order process. The median half-life of methanol in these patients was 43.1 hours, with a range of 30.3 to 52.0 hours. Conclusion: Because of the significantly increased risk of toxicity and complications during ethanol monotherapy, we suggest that hemodialysis be considered for methanol-poisoned patients who are treated with ethanol infusion. [Palatnick W, Redman LW, Sitar DS, Tenenbein M: Methanol half-life during ethanol administration: Implications for management of methanol poisoning. Ann Emerg Med August 1995;26:202-207.]
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 | From the Departments of Emergency*, Medicine‡, Pharmacology§, and Pediatrics , University of Manitoba; and the Westman Laborabory¶, Brandon, Manitoba, Canada. |
| Address for reprints: Milton Tenenbein, MD, FRCPC, Children's Hospital, 840 Sherbrook Street, Winnipeg, Manitoba R3A 1S1, Canada, 204-787-2445, Fax 204-787-4807 |
 | Reprint no. 47/1/65946 |
Vol 26 - N° 2
P. 202-207 - août 1995 Retour au numéro
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