Hemochromatosis screening in asymptomatic ambulatory men 30 years of age and older - 12/09/11
Abstract |
Objective |
To perform a cost-benefit analysis of screening for hereditary hemochromatosis.
Patients and methods |
A total of 3,977 consecutive men ≥30 years of age who presented for routine health checkups at a health maintenance organization medical center were screened for hereditary hemochromatosis by measuring transferrin saturation. Subjects with repeated transferrin saturation ≥62% and ferritin level ≥500 ng/mL (≥500 μg/L) were referred for liver biopsy. Subjects wim transferrin saturation <15% were referred for evaluation. Laboratory testing, screening, and abnormal screening test evaluation procedures were identified by chart review.
results |
Forty patients had transferrin saturation ≥62%. One hundred seventy-two had transferrin saturation <15%. Eight patients with hemochromatosis were identified. The 3 patients most seriously affected had hepatic iron concentrations >250 μmol/g dry weight. Two of them had hepatic fibrosis. Seven cases of hemochromatosis were found among 1,974 white subjects who were screened. Only 1 case was found among the remaining subjects.
conclusions |
Our observations support routine screening with transferrin saturation for white men ≥30 years of age.
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Vol 98 - N° 5
P. 464-468 - mai 1995 Retour au numéro
Article précédent
- Cyclical etidronate plus ergocalciferol prevents glucocorticoid-induced bone loss in postmenopausal women
- Terrence Diamond, Lou McGuigan, Sue Barbagallo, Carl Bryant
- Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus
- Andrea Griesmacher, Marlene Kindhauser, Sylvia E. Andert, Wolfgang Schreiner, Cyril Toma, Paul Knoebl, Peter Pietschmann, Rudolf Prager, Christoph Schnack, Guntram Schemthaner, Mathias M. Mueller
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