Elevated endothelin levels are associated with increased placental resistance - 12/09/11
Abstract |
OBJECTIVE: The purpose of this study was to measure cord blood endothelin-1,2 concentrations in growth-restricted infants with abnormal flow velocity waveforms. STUDY DESIGN: Endothelin-1,2 concentrations were measured by radioimmunoassay in the cord blood of 16 growth-restricted infants with abnormal flow velocity waveforms before delivery, 16 growth-restricted infants with normal flow velocity waveforms before delivery, and 44 appropriately grown infants. Clinical data regarding pregnancy complications and neonatal outcome were collected. RESULTS: The mean endothelin-1,2 concentration in growth-restricted infants with abnormal flow velocity waveforms (50.2 ± 16.4 pg/ml) was significantly higher than in growth-restricted infants with normal flow velocity waveforms (33.3 ± 14.2 pg/ml, p < 0.05) or in appropriately grown infants (25.8 ± 9.7 pg/ml, p < 0.05). Oligohydramnios was also associated with elevated endothelin levels. CONCLUSION: We conclude that endothelin-1,2 concentrations are elevated in growth-restricted infants with abnormal flow velocity waveforms and may play a role in the development of abnormal fetoplacental resistance. (AM J OBSTET GYNECOL 1996;174:1599-604.)
Le texte complet de cet article est disponible en PDF.Keywords : Endothelin, fetal growth restriction, umbilical velocimetry, oligohydramnios
Plan
| ☆ | From the Divisions of Newborn Medicine and Maternal-Fetal Medicine, Departments of Pediatricsaand Obstetrics and Gynecology,bFloating Hospital for Children, New England Medical Center, Tufts University School of Medicine. |
| ☆☆ | Reprint requests: Karen B. Harvey-Wilkes, MD, Department of Pediatrics (Newborn Medicine), New England Medical Center, Box 44, 750 Washington St., Boston, MA 02111. |
| ★ | 0002-9378/96 $5.00 + 0 6/1/70001 |
Vol 174 - N° 5
P. 1599-1604 - mai 1996 Retour au numéro
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