Antimüllerian hormone as a serum marker of granulosa cell tumors of the ovary: Comparative study with serum ⍺-inhibin and estradiol - 11/09/11
Abstract |
OBJECTIVE: Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors. STUDY DESIGN: Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, ⍺-inhibin, and estradiol levels were compared in 10 patients with a granulosa cell tumor during 6 to 47 months of follow-up. RESULTS: Serum antimüllerian hormone was undetectable in normal postmenopausal women and was <5 μg/L in premenopausal women. Normal serum levels were found in patients with ovarian cancers or cysts or with extraovarian cancers. Levels were between 6.8 and 117.9 μg/L in eight of nine patients with a progressive granulosa cell tumor. In the remaining case antimüllerian hormone, ⍺-inhibin and estradiol concentrations were normal. Serum antimüllerian hormone and ⍺-inhibin levels became elevated at least 11 months before the recurrence was clinically detectable. During clinical remission serum antimüllerian hormone, ⍺-inhibin, and estradiol were normal in most cases. CONCLUSION: Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early. (AM J OBSTET GYNECOL 1996;174:958-65.)
Le texte complet de cet article est disponible en PDF.Keywords : Antimüllerian hormone, müllerian inhibiting substance, inhibin, estradiol, granulosa cell tumor
Plan
 | From the Unité de Recherches sur l'Endocrinologie du Développement (Institut National de la Santé et de la Recherche Médicale), Département de Biologie, Ecole Normale Supérieure,a the Service d'Immunologie Moléculaire, Département de Biologie Clinique,b the Service de Gynécologie,c and the Service d'Anatomie Pathologique B,d Institut Gustave Roussy, and the Laboratoire de Biologie Hormonale (Institut National de la Santé et de la Recherche Médicale), Hôpital Saint Vincent de Paul.e |
| Supported in part by Contrat de Recherche Clinique grant No. 95.4, Institut Gustave Roussy, Villejuif, France, and by the Association pour la Recherche sur le Cancer, France. |
 | Reprint requests: Rodolfo Rey, MD, PhD, Institut National de la Santé et de la Recherche Médicale U.293, 1 Rue Maurice Arnoux, 92120 Montrouge, France. |
| 0002-9378/96 $5.00 + 0 6/1/68970 |
Vol 174 - N° 3
P. 958-965 - mars 1996 Retour au numéro
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