Ventricular premature beat—driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia - 11/09/11
Reprint requests: Heung Sik Na, MD, Department of Physiology, College of Medicine, Korea University, 126-1 Anam-dong 5 ga, Sungbuk-gu, Seoul, Korea 136-705.Abstract |
With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10-minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., “ischemic preconditioning”). Our results suggest that the VPB-driven intermittent reperfusion (i.e., “postconditioning”) is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
Le texte complet de cet article est disponible en PDF. | Supported in part by nondirected research fund from the Korea University College of Medicine. |
Vol 132 - N° 1P1
P. 78-83 - juillet 1996 Retour au numéro
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