Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome - 11/09/11

Doi : 10.1016/S0887-8994(96)00217-2

Toshimasa Obonai, MD ^⁎,^*, Sachio Takashima, MD ^*, Laurence E. Becker, MD ^†, Masami Asanuma, MD ^‡, Ryuzo Mizuta, MD ^§, Hiroshi Horie, MD , Junichi Tanaka ^¶
^* From the Department of Mental Retardation and Birth Defect Research; National Institute of Neuroscience; National Center of Neurology and Psychiatry; Kodaira, Tokyo, Japan
^† Department of Pathology; The Hospital for Sick Children; Toronto, Ontario, Canada
^‡ Department of Pathology; Matsudo Municipal Hospital; Matsudo, Chiba, Japan
^§ Department of Pediatrics, Kyoto 2nd Red Cross Hospital; Kyoto, Japan
Department of Pathology; Chiba Children's Hospital; Chiba, Japan
^¶ Department of Neuropathology; Institute of Neuroscience; The Jikei University School of Medicine; Tokyo, Japan

^**Communications should be addressed to: Dr. Obonai; Department of Mental Retardation and Birth Defect Research; National Institute of Neuroscience; National Center of Neurology and Psychiatry; 4-1-1 Ogawahigashi; Kodaira, Tokyo, Japan

Abstract

Substance P and glial fibrillary acidic protein (GFAP) immunohistochemistry was applied to the medulla of neonatal infants who died of sudden infant death syndrome (SIDS). A quantitative analysis of cells demonstrating immunoreactivity to GFAP and substance P in 15 neonatal SIDS cases revealed increased GFAP immunoreactivity in the reticular formation, the dorsal vagal nucleus, and the solitary nucleus and an increase in substance P immunoreactivity in the spinal trigeminal nucleus and the solitary nucleus as compared with that in age-matched controls. GFAP immunopositivity suggests astrogliosis which implies a pathologic insult to neurons in the area of astrogliosis. The failure of neurons in these sites to show enhanced substance P immunopositivity may indirectly indicate altered neurons. Further study of prenatal events may be of importance in clarifying the pathogenesis of neonatal SIDS.

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This work was supported by grants from the Ministries of Health and Welfare, and Education and Culture, Japan.

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Vol 15 - N° 3

P. 189-192 - octobre 1996 Retour au numéro

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Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome - 11/09/11

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