Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally γ-irradiated mice - 11/09/11
, Milan Pospíšil a, Ladislav Dušek b, Zuzana Hoferová a, Lenka Weiterová a
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Abstract |
Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor meloxicam and an adenosine A3 receptor agonist IB-MECA. The drugs were administered in an early postirradiation treatment regimen: meloxicam was given in a single dose 1hour after irradiation, IB-MECA in two doses 24 and 48hours after irradiation. Treatment-induced changes in several compartments of hematopoietic progenitor and precursor cells of the bone marrow were evaluated on day 3 after irradiation. Values of hematopoietic progenitor cells for granulocytes/macrophages and erythrocytes (GM-CFC and BFU-E, respectively), as well as those of proliferative granulocytic cells were found to be significantly higher in the mice treated with the drug combination in comparison to irradiated controls and attained the highest increase factors of 1.6, 1.6, and 2.6, respectively. The study emphasizes the significance of the combined treatment of suppressed hematopoiesis with more agents. Mechanisms of the action of the individual compounds of the studied drug combination and of their joint operation are discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Hematopoiesis, COX-2 inhibitor, Adenosine A3 receptor agonist
Abbreviations : COX-1, COX-2, NSAIDs, GM-CFC, BFU-E, IB-MECA, G-CSF
Plan
Vol 65 - N° 6
P. 427-431 - septembre 2011 Retour au numéro
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