Verrucosis of hands and feet in a patient with combined immune deficiency - 11/09/11
From the Departments of Dermatologya and Medical Immunology, c University Hospital Charité, Berlin, and the Departments of Clinical Chemistry/Biochemistryb and Pediatrics,e Virchow-Klinikum, Humboldt University, Berlin; and general practice, d Siegen.
Abstract |
In immunocompromised patients, warts occur frequently and can be extensive. We describe a 24-year-old patient with severe therapy-resistant warts. In addition to human papillomavirus infection, he had chronic sinusitis, candidiasis, and atopic dermatitis. Anergy to delayed-type hypersensitivity skin test reaction, significant CD4 lymphopenia, and diminished in vitro T-cell proliferative response and interferon-γ production indicated a deficiency of cellular immunity. Extremely low concentrations of serum IgM and IgG2 and a severe deficiency of in vitro IgM production pointed also to a humoral immunodeficiency syndrome. This case represents a combination of cellular and humoral immunodeficiencies that has not been previously described in association with warts. (J Am Acad Dermatol 1997;36:850-2.)
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 | Reprint requests: Khusru Asadullah, MD, Department of Dermatology, University Hospital Charité, Berlin Humboldt University, D-10098 Berlin, Germany. |
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Vol 36 - N° 5S
P. 850-852 - mai 1997 Retour au numéro
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