Methotrexate-induced toxic epidermal necrolysis in a patient with psoriasis - 11/09/11
Doi : 10.1016/S0190-9622(97)70029-X
Abstract |
We describe a fatal case of low-dose methotrexate (MTX) toxicity in a patient with psoriasis, emphasizing the factors that exacerbate MTX toxicity and presenting rescue techniques. The patient had a toxic epidermal necrolysis-like condition. MTX cutaneous reactions ranging from toxic epidermal necrolysis to specific ulcerations have been described. The use of granulocyte colony stimulating factor for leukopenia associated with MTX toxicity is discussed. (J Am Acad Dermatol 1997;36:815-8.)
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 | This article is made possible through an educational grant from the Dermatological Division, Ortho Pharmaceutical Corporation. |
| Corresponding author: Edward J. Primka, MD, 31726 Maritime Ct., Avon Lake, OH 44012. |
 | No reprints available from author. |
| 0190-9622/97/$5.00 + 0 16/4/77518 |
© 1997
American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 36 - N° 5S
P. 815-818 - mai 1997 Retour au numéro
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