Skin distribution and pharmaceutical aspects of adapalene gel - 11/09/11
Abstract |
Background: The formulation of topical dermatologic products must take into account efficacy, safety, and patient compliance.
Objective: We describe how an aqueous gel containing adapalene, a novel naphthoic acid derivative, was selected for the topical treatment of acne.
Methods and Results: Dose selection was made using established in vivo models. In the Rhino mouse the comedolytic effect of adapalene 0.1% gel was similar or superior to that of a reference formulation containing 0.025% tretinoin. Qualitative distribution of adapalene after topical application was assessed on cryosections of human skin. They showed rapid penetration of adapalene into the pilosebaceous unit. A liberation/penetration study demonstrated that significant quantities of adapalene were present in epidermis and dermis, but only 0.01% of the applied dose penetrated through the skin.
Conclusion: This formulation should result in effective and well-tolerated treatment of acne vulgaris with good patient compliance. (J Am Acad Dermatol 1997;36:S119-25.)
Le texte complet de cet article est disponible en PDF.Plan
 | Reprint requests: Alain Chatelus, PhD, CIRD Galderma, 635 Route des Lucioles, 06902 Sophia Antipolis Cedex, France. |
| 0190-9622/97/$5.00 + 0 16/0/81182 |
Vol 36 - N° 6S
P. S119-S125 - juin 1997 Retour au numéro
Article précédent
- Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients
- Alan Clucas, Michèle Verschoore, Valérie Sorba, Michel Poncet, Mike Baker, Janusz Czernielewski, From CIRD Galderma, Sophia Antipolis.
- Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials
- W.J. Cunliffe, R. Caputo, B. Dreno, L. Förström, M. Heenen, C.E. Orfanos, Y. Privat, A.Robledo Aguilar, J. Meynadier, Mohsen Alirezai, S. Jablonska, A. Shalita, J.S. Weiss, D.K. Chalker, C.N. Ellis, A. Greenspan, H.I. Katz, I. Kantor, L.E. Millikan, J.M. Swinehart, L. Swinyer, C. Whitmore, J. Czernielewski, M. Verschoore
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?