PARKINSON'S DISEASE - 11/09/11

Doi : 10.1016/S0193-953X(05)70344-0

Egberto Reis Barbosa, MD, PhD ^a, João Carlos Papaterra Limongi, MD, PhD ^a, Jeffrey L. Cummings, MD ^b

^a Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School. São Paulo, Brazil. (ERB, JCPL).

^b Departments of Neurology and Psychiatry, and Alzheimer's Disease Center, University of California at Los Angeles Medical School. Los Angeles, California. (JLC)

Résumé

Parkinson's disease (PD) is a neurodegenerative disorder characterized by tremor at rest, akinesia, rigidity, postural abnormalities, and episodes of motor arrest. Although these motor phenomena constitute the major group of symptoms, there also can be disturbances in other nonmotor spheres of neurologic function, such as cognitive, psychiatric, and autonomic changes.

PD is one of the most common neurologic disorders seen in clinical practice, and it affects all races and both genders with a slight predominance in men. Its incidence is approximately 20 cases per 100,000 inhabitants per year; its prevalence ranges from 150 to 200 cases per 100,000 inhabitants in the general population and increases steadily with age. Prevalence rises to 500 per 100,000 above 50 years of age and to 1% above age 65.^{57 Rajput A.H., Offord A.P., Bear C.M. , et al. Epidemiology of Parkinson's disease: Incidence, classification and mortality Ann Neurol 1984 ; 16 : 78-132

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Plan

Address reprint requests to Egberto Reis Barbosa, MD, PhD, Hospital das Clínicas da Faculdade de Medicina, da Universidade de São Paulo, Departamento de Neurologia, Av. Dr. Enéas de Carvalho Aguiar, 255, CEP 05403–000