Early aggressive treatment for Merkel cell carcinoma improves outcome - 11/09/11
Abstract |
Background |
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of dermal origin. Treatment recommendations are limited owing to a paucity of retrospective data and an absence of prospective data. The objective of this study was to determine current therapeutic trends and their impact upon outcome.
Methods |
A retrospective study (1983 to 1996) was performed with patients from the Department of Defense and our University-affiliated hospitals.
Results |
Thirty-five patients were evaluated with a mean follow-up of 31 months. Overall, 1- and 2-year survival rates were 80% and 50%, respectively. Patients undergoing wide local excision, prophylactic lymph node dissection, and adjuvant radiotherapy had significantly decreased locoregional and distant recurrence rates and improved survival when compared with their counterparts. Adjuvant chemotherapy did not diminish recurrence rates nor improve survival. Both locoregional and distant recurrence significantly decreased survival.
Conclusions |
These data suggest that early aggressive treatment for MCC improves both tumor control and survival, whereas the early use of chemotherapy does not improve outcome.
Le texte complet de cet article est disponible en PDF.| ** | Presented at the 49th Annual Meeting of the Southwestern Surgical Congress, Rancho Mirage, California, April 13–16, 1997. |
Vol 174 - N° 6
P. 688-693 - décembre 1997 Retour au numéro
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