Maternal serum screening for Down syndrome in the United States: A 1995 survey - 10/09/11
Abstract |
OBJECTIVE: Our goal was to determine the status of prenatal Down syndrome screening in the United States in 1995.
STUDY DESIGN: Information was sought via questionnaire from laboratories participating in external proficiency testing.
RESULTS: Services were provided to 2,498,000 women annually by 265 screening laboratories. All but 10 laboratories offered both open neural tube defect and Down syndrome screening. Twenty-one percent of Down syndrome interpretations were based on ⍺-fetoprotein measurements alone; 79% also included other serum analytes. Sixty-six laboratories (26%) offered interpretations at 14 weeks' gestation or earlier.
CONCLUSIONS: Some laboratories extend serum screening too early in gestation for optimal neural tube defect interpretation. When 1995 was compared with 1992, more women were being screened, a higher proportion were receiving a Down syndrome interpretation, and more interpretations were based on multiple analytes. Laboratories should be encouraged to use some combination of multiple markers when screening for Down syndrome. (Am J Obstet Gynecol 1997;176:1046-51.)
Le texte complet de cet article est disponible en PDF.Keywords : Prenatal screening, Down syndrome, ⍺-fetoprotein, unconjugated estriol, human chorionic gonadotropin
Plan
 | From the Foundation for Blood Researcha and the Department of Pathology, Bellevue Maternity Hospital.b |
| Supported in part by the New England Regional Genetics Group, Project MCJ-251003-07 from the Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, Department of Health and Human Services. |
 | Reprint requests: Glenn E. Palomaki, BS, Foundation for Blood Research, PO Box 190, Scarborough, ME 04070-0190. |
| 0002-9378/97 $5.00 + 0 6/1/80580 |
Vol 176 - N° 5
P. 1046-1051 - mai 1997 Retour au numéro
Article précédent
- Exposure of an infant to cervical human papillomavirus infection of the mother is common
- Mirja H. Puranen, Merja H. Yliskoski, Seppo V. Saarikoski, Kari J. Syrjänen, Stina M. Syrjänen
- Comparison of intraocular pressure between normotensive and preeclamptic women in the peripartum period
- Gregg Giannina, Michael A. Belfort, Pauline Abadejos, Karen Dorman
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?