Hemostasis in newborns of smoking and nonsmoking mothers - 10/09/11
Abstract |
OBJECTIVE: Our purpose was to determine the effect of smoking during pregnancy on neonatal hemostasis.
STUDY DESIGN: Venous blood samples of 26 newborns of smoking and 25 newborns of nonsmoking mothers were obtained from the clamped umbilical cord immediately after birth. Prothrombin fragment 1+2, thrombin–antithrombin III complex, plasmin–⍺2-antiplasmin complex, and d-dimer levels were determined to assess activation of coagulation and fibrinolysis. Cotinine was measured in all neonates to objectify cigarette smoke exposure. The Mann-Whitney U test was used to compare the differences between the values of the parameters of coagulation and fibrinolysis in the two groups at the p < 0.05 level.
RESULTS: The median values of prothrombin fragment 1+2 and thrombin–antithrombin III complex in newborns exposed to tobacco smoke in utero did not differ from values of newborns who were not exposed. Nor were the markers of fibrinolysis, plasmin–⍺2-antiplasmin complex and d-dimer levels, influenced by tobacco smoke exposure.
CONCLUSION: The balance between the components of coagulation and fibrinolytic pathways in neonates is not disturbed by maternal smoking.(Am J Obstet Gynecol 1997;176:662-6
Le texte complet de cet article est disponible en PDF.Keywords : Maternal smoking, neonates, coagulation, fibrinolysis
Plan
 | From the Departments of Obstetrics and Gynaecologya and Haematology,b De Wever Hospital. |
| Reprint requests: J.W.J. van Wersch, PhD, Department of Haematology, De Wever Hospital, P.O. Box 4446, 6401 CX Heerlen, The Netherlands. |
 | 0002-9378/97 $5.00 + 0 6/1/79148 |
Vol 176 - N° 3
P. 662-666 - mars 1997 Retour au numéro
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