A comparison of myogenic and endothelial properties of myometrial and omental resistance vessels in late pregnancy - 10/09/11
Abstract |
OBJECTIVE: Our purpose was to compare myometrial and omental resistance arteries from term pregnant women with respect to myogenic behavior in the presence or absence of a nitric oxide synthase inhibitor and to compare distensibility and acetylcholine-mediated dilatation in these vessels.
STUDY DESIGN: Intramyometrial (n = 17) and omental (n = 14) resistance arteries from term normal pregnant women were studied in a pressurized arteriograph system. Myogenic tone was evaluated during increments in intraluminal pressure from 20 to 120 mm Hg with and without inhibition of nitric oxide synthase. Endothelium-dependent relaxation was assessed by evaluating the response to acetylcholine (10–6 mol/L) in arteries pressurized at 70 mm Hg.
RESULTS: Myogenic tone was greater at all pressure steps in the myometrial than in the omental arteries (p < 0.05). Inhibition of nitric oxide synthase with Nω-nitro-l-arginine had no influence on myogenic tone in either group. Relaxation to acetylcholine was greater in myometrial (18% ± 4%) compared with omental vessels (7% ± 2%, p < 0.05). The passive distensibility (Ca++-free solution and in the presence of papaverine) of arteries from the myometrium and the omentum was similar.
CONCLUSION: Normal pregnancy is associated with different mechanical properties of resistance vessels from the two vascular beds studied. Basal nitric oxide release does not modify myogenic tone, at least under no-flow conditions. Acetylcholine-induced relaxation is greater in myometrial than in omental arteries. (Am J Obstet Gynecol 1997;176:560-6
Le texte complet de cet article est disponible en PDF.Keywords : Pregnancy, resistance arteries, myogenic, nitric oxide, acetylcholine
Plan
 | From the Departments of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital,aUppsala University.b |
| Supported by grants from the Karolinska Institute, the Swedish Medical Research Council (grant No. 9512), the Swedish Society of Medicine, and the General Maternity Hospital Memory Foundation. |
 | Reprint requests: Karolina-Rasa Kublickiene, MD, Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden. |
| 0002-9378/97 $5.00 + 0 6/1/79569 |
Vol 176 - N° 3
P. 560-566 - mars 1997 Retour au numéro
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