Undetectable maternal serum unconjugated estriol levels in the second trimester: Risk of perinatal complications associated with placental sulfatase deficiency - 10/09/11
Abstract |
OBJECTIVE: Our purpose was to determine the prevalence of undetectably low second-trimester maternal serum unconjugated estriol levels and the association with increased perinatal morbidity or mortality in pregnancies at risk for placental sulfatase deficiency.
STUDY DESIGN: Nine centers in New England identified singleton pregnancies with undetectably low unconjugated estriol levels. Each unexplained case was matched with four controls; pregnancy outcome information was sought.
RESULTS: Among 130,295 pregnancies surveyed, undetectably low unconjugated estriol levels were identified in 167 (13/10,000). Explanations included fetal death (53), overestimated gestational age (50), nonpregnancy (12), and chromosome abnormalities (5). The 41 unexplained cases were compared with 163 matched controls. Male offspring were more frequent (85%) among cases than among controls (55%). Although rates of perinatal complications were not significantly different, primary cesarean sections occurred about twice as often among cases. No perinatal deaths occurred.
CONCLUSIONS: Neither severity of symptoms nor perinatal morbidity or mortality currently warrant routine interpretation of unexplained undetectably low unconjugated estriol levels as a marker for placental sulfatase deficiency.(Am J Obstet Gynecol 1997;176:531-5
Le texte complet de cet article est disponible en PDF.Keywords : Prenatal screening, unconjugated estriol, placental sulfatase deficiency
Plan
From the Foundation for Blood Researcha and the Women and Infants Hospital and Brown University.b |
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Supported by the New England Regional Genetics Group and by the Department of Health and Human Services, Bureau of Maternal and Child Health, PHS grant No. MCJ-251003-09. |
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Reprint requests: Linda A. Bradley, PhD, Foundation for Blood Research, P.O. Box 190, Scarborough, ME 04070-0190. |
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0002-9378/97 $5.00 + 0 6/1/78869 |
Vol 176 - N° 3
P. 531-535 - mars 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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