Absence of neuronal damage after umbilical cord occlusion of 10, 15, and 20 minutes in midgestation fetal sheep - 10/09/11
Abstract |
OBJECTIVES: Our purpose was to determine whether neuronal damage results after total umbilical cord occlusion of increasing duration in midgestation fetal sheep.
STUDY DESIGN: We performed total umbilical cord occlusion during 10 (n = 11), 15 (n = 8), or 20 (n = 4) minutes in chronically instrumented midgestation fetal sheep. Nine fetuses served as sham controls. During the experiment fetal blood pressure (mean arterial pressure) and heart rate were continuously recorded. Fetal blood gas analyses were performed at regular intervals before, during, and after the occlusion. Three days after the occlusion neuronal damage was evaluated histologically in three regions of the fetal brain.
RESULTS: Total umbilical cord occlusion resulted in hypotension, bradycardia, severe mixed acidemia, hypoxia, and hypercapnia. All fetuses survived the occlusion. No neuronal damage nor macroscopic intraventricular or germinal matrix hemorrhages were observed in either group.
CONCLUSION: Prolonging the duration of total umbilical cord occlusion in midgestation fetal sheep resulted in a progressive increase in the severity of asphyxia, not in neuronal damage.(Am J Obstet Gynecol 1997;176:515-20)
0002-9378/97 $5.00 + 0
Le texte complet de cet article est disponible en PDF.Keywords : Asphyxia, immature, sheep, neuronal damage
Plan
 | From the Departments of Obstetrics and Gynecologya and Neonatology,b University Hospital Maastricht, and the Department of Life Sciences, Janssen Research Foundation.c |
| Reprint requests: Tom H.M. Hasaart, MD, PhD, Department of Obstetrics and Gynecology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. |
 | 6/1/79498 |
Vol 176 - N° 3
P. 515-520 - mars 1997 Retour au numéro
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