Increased renal formation of thromboxane A2 and prostaglandin F2⍺ in heart failure - 10/09/11
Abstract |
Renal formation of the vasoconstrictor prostaglandins thromboxane A2 (TXA2 ) and prostaglandin F2⍺ (PGF2⍺ ) was investigated in 25 patients with cardiac failure, divided into New York Heart Association functional classes I to IV, and in eight healthy control subjects. Plasma renin activity (PRA) and hemodynamic parameters were also investigated. Renal vasoconstrictor eicosanoid formation, measured in urinary daily excretion, was not different between patients in class I and control subjects. Class II to IV patients showed progressively increasing production of PGF2⍺ (F = 49.8, p < 0.001, analysis of variance) and TXA2 (F = 37.8, p < 0.002). PGF2⍺ excretion peaked in class IV (+1266% vs class I, p < 0.001). Compared with class I, urinary excretion of thromboxane B2 was +816% in class III and +1561% in class IV (both p < 0.001). PRA was significantly increased only in class IV (+1558%, p < 0.001). The current results indicate a progressive increase in renal production of vasoconstrictor eicosanoids directly related to New York Heart Association class and suggest that these prostanoids may have a role in deterioration of renal function. (Am Heart J 1997;133:94-100.)
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 | From athe Clinica Medica Generale e Cardiologia, University of Florence, and b the Istituto di Gerontologia e Geriatria, University of Florence. |
| Reprint requests: Sergio Castellani, MD, Clinica Medica Generale e Cardiologia, Viale Morgagni, 85, 50134, Firenze, Italy. |
 | 4/1/77198 |
Vol 133 - N° 1
P. 94-100 - janvier 1997 Retour au numéro
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