Signalling mechanisms in Mycobacteria - 10/09/11

Doi : 10.1016/j.tube.2011.04.005

Pradip K. Chakraborti ^a,^{^{1
Fax: +91 172 2690585, +91 172 2690132.}} , Nishad Matange ^b, Vinay K. Nandicoori ^c,^{^{2
Fax: +91 11 26742125, +91 11 26742626.}} , Yogendra Singh ^d,^{^{3
Fax: +91 011 27667471.}} , Jaya S. Tyagi ^e,^{^{4
Fax: +91 11 26588663.}} , Sandhya S. Visweswariah ^b,^⁎
^a Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India
^b Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
^c National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
^d Institute of Genomics and Integrative Biology (CSIR), Near Jubilee Hall, Mall Road, Delhi 110 007, India
^e Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India

Corresponding author. Fax: +91 80 23600999.

Summary

The importance of inter- and intracellular signal transduction in all forms of life cannot be underestimated. A large number of genes dedicated to cellular signalling are found in almost all sequenced genomes, and Mycobacteria are no exception. What appears to be interesting in Mycobacteria is that well characterized signalling mechanisms used by bacteria, such as the histidine-aspartate phosphorelay seen in two-component systems, are found alongside signalling components that closely mimic those seen in higher eukaryotes. This review will describe the important contribution made by researchers in India towards the identification and characterization of proteins involved in two-component signalling, protein phosphorylation and cyclic nucleotide metabolism.

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Keywords : Cyclic AMP, DevR, DevS, Protein kinase, Phosphodiesterase