Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge - 10/09/11
Corresponding author. Center for Tuberculosis Research, 1550 Orleans Street, Rm 109, Baltimore, MD 21231, USA. Tel.: +1 410 614 8241; fax: +1 410 614 8173.Summary |
Clinical reports suggest an association of distinct Mycobacterium tuberculosis strains with CNS disease. We therefore examined CNS dissemination by different laboratory strains (two M. tuberculosis H37Rv, one CDC1551) in a guinea pig aerosol infection model. Although all strains grew exponentially in lungs, with similar bacterial burdens at the time of extrapulmonary dissemination, M. tuberculosis CDC1551 disseminated to the CNS significantly more than the H37Rv strains. No CNS lesions were observed throughout the study, with only a modest cytokine response. These data suggest that M. tuberculosis may have virulence factors that promote CNS dissemination, distinct from those required for pulmonary TB.
Le texte complet de cet article est disponible en PDF.Keywords : Tuberculosis, Central nervous system, Meningitis, Dissemination, Guinea pig
Plan
Vol 91 - N° 5
P. 386-389 - septembre 2011 Retour au numéro
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