N-terminal proANF in acute atrial fibrillation: A biochemical marker of atrial pressures but not a predictor for conversion to sinus rhythm - 09/09/11
For the Digitalis in Acute Atrial Fibrillation (DAAF) Trial group
Abstract |
Background: Atrial filling pressures are increased in acute atrial fibrillation, which stimulates the release of atrial natriuretic factor pro-hormone, proANF. Methods: In a randomized trial comparing digoxin with placebo in 216 patients, we investigated whether the baseline plasma level of N-terminal proANF is a predictor for conversion to sinus rhythm and the relation among N-terminal proANF, conversion to sinus rhythm, and changes in heart rate. Results: N-terminal proANF was increased at baseline and decreased significantly in patients converting to sinus rhythm, whereas it was mainly unchanged in nonconverters. N-terminal proANF was not a predictor of conversion to sinus rhythm. A relation was found between relative changes in heart rate and N-terminal proANF in nonconverters. Conclusion: The level of N-terminal proANF does not predict conversion to sinus rhythm, which indicates that hemodynamics per se is not important. There is a correlation between relative changes in heart rate and N-terminal proANF in nonconverters. (Am Heart J 1998;135:1040-7.)
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 | From the Departments of aInternal Medicine and Cardiology of Östra University Hospital (Göteborg), cVarberg, dMölndal, e Uddevalla, and fLidköping; and the bInstitute for Surgical Research, Oslo. |
| Reprint requests: Björn Hornestam, MD, Division of Cardiology, Department of Internal Medicine, Sahlgrenska University Hospital, S- 413 45 Göteborg, Sweden. |
 | 4/1/89191 |
Vol 135 - N° 6
P. 1040-1047 - juin 1998 Retour au numéro
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