Induced sputum and response to glucocorticoids - 09/09/11
Abstract |
Jerry Dolovich has generated substantial new work that has had an international impact on the understanding and treatment of asthma and other airway diseases. For this, he is recognized as a Distinguished Clinician of the American Academy of Asthma, Allergy and Immunology. I have focused on some of his recent work with us using induced sputum to measure indices of airway inflammation noninvasively. The results illustrate that sputum eosinophilia (1) does not necessarily correlate with the severity of symptoms or severity of abnormalities of airway function, (2) does not always occur in exacerbations of asthma, and (3) may be a predictor clinical benefit to steroid treatment, which will be useful in practice. The observations imply that airway inflammation needs to be measured to understand the pathogenesis, pathophysiology, and treatment of asthma and other airway diseases. (J Allergy Clin Immunol 1998;102:S102-5.)
Le texte complet de cet article est disponible en PDF.Abbreviations : BAL:
Plan
From the Department of Medicine, McMaster University, Hamilton. |
|
Reprint requests: Frederick E. Hargreave, MD, FRCP(C), FRCP, Firestone Regional Chest & Allergy Unit, McMaster University and St Joseph’s Hospital, 50 Charlton Ave E, Hamilton, ON, Canada L8N 4A6. |
|
0091-6749/98 $5.00 + 0 1/0/93905 |
Vol 102 - N° 5
P. S102-S105 - novembre 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?