Low-dose UVA₁ phototherapy for treatment of localized scleroderma - 09/09/11

Doi : 10.1016/S0190-9622(98)70533-X

Martina Kerscher, MD^a, Matthias Volkenandt, MD^b, Claus Gruss, MD^a, Tilmann Reuther, MD^a, Gregor von Kobyletzki, MD^a, Marcus Freitag, MD^a, Thomas Dirschka, MD^a, Peter Altmeyer, MD^a
Bochum, Munich, and Düsseldorf, Germany

Abstract

Background: For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. Objective: We attempted to determine the efficacy of low-dose UVA₁ irradiation in patients with severe localized scleroderma. Methods: Patients were irradiated with 20 J/cm ² UVA₁ for 12 weeks (total number of treatments: 30; cumulative UVA₁ dose: 600 J/cm²). Results: Low-dose UVA₁ irradiation induced significant clinical improvement (clearance of>80% of lesions) in 18 of 20 patients. Clearance was documented by clinical score as well as by 20 MHz ultrasound and histopathologic analysis. Conclusion: Low-dose UVA₁phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy. (J Am Acad Dermatol 1998;38:21-6.)

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Plan

Evaluation of treatment results

Assessment of clinical severity

20 MHz ultrasound analysis

Histopathologic analysis

Statistical analysis

RESULTS

DISCUSSION

	From the Departments of Dermatology, Ruhr-University Bochum, ^a Ludwig-Maximilians University Munich,^b and Heinrich-Heine University Düsseldorf.^c
	Reprint requests: Martina Kerscher, MD, Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany.
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