Cutaneous melanoma: Patient surveillance and tumor progression - 09/09/11
Abstract |
Background: The goal of surveillance examinations (SVE) in patients at high risk for cutaneous melanoma (CM) is to diagnose premetastatic tumors. Objective: We attempted to determine whether SVE before CM diagnosis influences the histopathologic features of tumor progression. Methods: A retrospective review was conducted of consecutive patients who presented with an intact primary CM during a 36 month period (1991 to 1994) in a university dermatology ambulatory setting. Results: Thirty-nine intact CMs were diagnosed in 34 patients. Compared with 23 CMs in as many patients presenting at the first encounter, 16 CMs diagnosed in 11 patients during SVE had a smaller mean tumor diameter (P = .007) and tumor thickness (P = .002) and were more likely anatomic level I or II (P = .003) with microscopic thickness less than 0.76 mm (P = .01) and less than 0.50 mm (P = .002). Conclusion: Primary CMs are more likely to be smaller and thinner when diagnosed during SVE than at first encounter, features that are likely to have a positive impact on CM mortality. (J Am Acad Dermatol 1998;39:571-7.)
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Support for Dr D’Amico was provided in part by Mercy Hospital, Pittsburgh, PA, where Dr Richert was a resident in the Department of Medicine when this study was initiated. |
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Reprint requests: Arthur R. Rhodes, MD, MPH, Department of Dermatology, University of Pittsburgh Medical Center, 3601 5th Ave, Pittsburgh, PA 15213. |
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0190-9622/98/$5.00 + 0 16/1/92718 |
Vol 39 - N° 4
P. 571-577 - octobre 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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