Acute Hepatic Failure in a Child Treated With Lamotrigine - 08/09/11
Doi : 10.1016/S0887-8994(97)00196-3
Ronen Arnon A, Darryl DeVivo B, Amy R. Defelice A, Philip G. Kazlow A, ⁎
A Department of Pediatrics; Division of Gastroenterology and Nutrition, Columbia University School of Medicine; New York, New York, USA
B Department of Pediatrics, Division of Neurology; Columbia University School of Medicine; New York, New York, USA.
*Dr. Kazlow; Department of Pediatrics; Columbia University; 630 West 168th Street, New York, NY 10032.
Abstract |
An 8-year-old boy with a known seizure disorder that was being treated with lamotrigine developed acute hepatic failure. The patient, who had been well previously, presented with jaundice, elevated liver enzymes, and a coagulopathy. After discontinuation of lamotrigine and aggressive resuscitation, the patient made an uneventful recovery. We believe that the hepatic failure in our patient was secondary to the use of lamotrigine. We recommend careful monitoring of liver function when lamotrigine is administered.
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© 1998
Elsevier Science Inc. Tous droits réservés.
Vol 18 - N° 3
P. 251-252 - mars 1998 Retour au numéro
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