Heparin has been the mainstay of acute anticoagulation therapy for decades. Within the past 20 years, several different heparin fractions—collectively known as low molecular weight heparins (LMWHs)—have been evaluated in various medical and surgical settings in which anticoagulation is routinely warranted. The LMWHs are efficacious, safe, cost-effective, and easier to administer and monitor than standard, unfractionated heparin. As LMWH use becomes more widespread, emergency physicians will use these new agents instead of unfractionated heparin for unstable angina, non–Q-wave myocardial infarction, or thromboembolic disease. This review focuses on the pharmacologic properties of unfractionated heparin and LMWH, associated complications, and the use of these agents in acute ischemic coronary syndromes, thromboembolic disease, and other selected clinical situations. [Hovanessian HC: New-generation anticoagulants: The low molecular weight heparins. Ann Emerg Med December 1999;34:768-779.]