Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate - 08/09/11
Abstract |
Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy. (J Pediatr 1999;134:368-70)
Le texte complet de cet article est disponible en PDF.Abbreviations : AIDS, CDC, HIV, IV, MA
Plan
 | Drs Stockheim and Chadwick received financial support from Bristol-Myers Squibb, the maker of Megace, to present this research in abstract form at the Fifth Conference on Retroviruses and Opportunistic Infections, Chicago, Illinois, February 1-5, 1998. |
| Reprints not available from author. |
 | 0022-3476/99/$8.00 + 0 9/22/96183 |
Vol 134 - N° 3
P. 368-370 - mars 1999 Retour au numéro
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