Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes - 08/09/11
Abstract |
Objective: To determine the efficacy of a short course of oral prednisolone as an adjuvant therapy for acute otitis media draining through tympanostomy tubes. Study design: In a randomized, double-blind, placebo-controlled study, children with acute discharge (<48 hours) through tympanostomy tubes received either prednisolone (2 mg/kg/d; n = 23) or placebo (n = 27) for 3 days. All children received amoxicillin/clavulanate (40/10 mg/kg/d) for 7 days. The children were examined daily at the study clinic until the drainage ceased. Results: The median duration of otorrhea in the prednisolone group was 1.0 days (25% to 75% range, 1.0 to 2.0 days), compared with 3.0 days (25% to 75% range, 2.0 to 4.0 days) in the children receiving placebo (P < .001). The duration of otorrhea was ≤2 days in 21 (91%) children in the prednisolone group, compared with 8 (30%) children in the placebo group (P < .001). Conclusions: Oral prednisolone appears to be modestly effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes in children. Further studies seem warranted to determine whether short-term use of steroids early during the course of acute otitis media would also reduce the duration of middle ear effusion in children with intact tympanic membranes. (J Pediatr 1999;134:459-63)
Le texte complet de cet article est disponible en PDF.Abbreviations : AOM, MEE, OME
Plan
Supported by grants from the Academy of Finland; the Foundation for Pediatric Research, Finland; and Emil Aaltonen Foundation, Finland. |
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Reprint requests: Aino Ruohola, MD, Department of Pediatrics, Turku University Hospital, FIN-20520 Turku, Finland. |
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0022-3476/99/$8.00 + 0 9/21/96796 |
Vol 134 - N° 4
P. 459-463 - avril 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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