Characterization of esophageal body and lower esophageal sphincter motor function in the very premature neonate - 08/09/11
Abstract |
Objectives: To characterize esophageal body and lower esophageal sphincter (LES) motor function in very premature infants. Study design: Esophageal manometry was performed in 12 very premature infants of 26 to 33 weeks’ postmenstrual age (PMA) (body weights of 610-1360 g). Esophageal motor patterns were recorded for 30 minutes with a perfused micromanometric sleeve assembly (outer diameter, 2.0 mm). Results: Esophageal pressure waves triggered by dry swallows were predominantly (84%) peristaltic in propagation sequence. All infants showed tonic LES contraction; the mean resting LES pressure (LESP) for individual infants ranged from 5.0 ± 4.1 mm Hg to 20.0 ± 4.8 mm Hg. In all infants the LES relaxed (duration, 5.8 ± 3.0 seconds; nadir pressure, 1.8 ± 2.6 mm Hg) in response to pharyngeal swallows. Transient LES relaxations (TLESRs) (duration, 21.7 ± 8.7 seconds; nadir pressure, 0.1 ± 1.8 mm Hg) occurred on average 2.6 ± 1.6 times per study; 86% of these relaxations triggered esophageal body common cavity events known to be associated with gastroesophageal reflux. Conclusions: Esophageal motor function is well developed in very premature infants. Our data also suggest that TLESR is the predominant mechanism of reflux in these babies. (J Pediatr 1999;135:517-21)
Le texte complet de cet article est disponible en PDF.Abbreviations : GER, LES, LESP, LESR, PMA, TLESR
Plan
Supported by National Health and Medical Research Council of Australia and Women’s and Children’s Hospital Research Foundation. Dr Benninga’s involvement in this project was supported by the Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, the Netherlands Organisation for Scientific Research and the Netherlands Digestive Diseases Foundation. |
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Reprint requests: Taher I. Omari, BSc, PhD, Gastroenterology Unit, Women’s and Children’s Hospital, 72 King William Rd, North Adelaide, Australia 5006. |
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0022-3476/99/$8.00 + 0 9/22/100093 |
Vol 135 - N° 4
P. 517-521 - octobre 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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