Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream - 07/09/11
Abstract |
Background: Basal cell carcinoma (BCC) responds to interferon therapy. Imiquimod is a cytokine and interferon inducer. Objective: This randomized, double-blind pilot trial evaluated the safety and efficacy of imiquimod 5% cream versus vehicle in the treatment of BCC. Methods: In this population of 35 patients with BCC, 24 received imiquimod 5% cream and 11 received vehicle cream in 1 of 5 dosing regimens for up to 16 weeks. Six weeks after treatment, an excisional biopsy of the target site was performed. Results: BCC cleared (on the basis of histologic examination) in all 15 patients (100%) dosed twice daily, once daily, and 3 times weekly; in 3 of 5 (60%) patients dosed twice weekly; 2 of 4 (50%) dosed once weekly; and in 1 of 11 (9%) treated with vehicle. Adverse events were predominantly local reactions at the target tumor site, with the incidence and severity of local skin reactions declining in groups dosed less frequently. Conclusion: Imiquimod 5% cream shows clinical efficacy in the treatment of BCC. (J Am Acad Dermatol 1999;41:1002-7.)
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Supported by a grant from 3M Pharmaceuticals, St Paul, Minnesota. |
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Reprint requests: Karl Beutner, MD, PhD, Solano Dermatology Associates, 127 Hospital Dr, Ste 204, Vallejo, CA 94589. |
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0190-9622/99/$8.00 + 0 16/1/101291 |
Vol 41 - N° 6
P. 1002-1007 - décembre 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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