Of the 184,500 patients anticipated to be diagnosed with prostate cancer in 1998, approximately 20% will have metastatic disease at the time of diagnosis.<sup>46 Landis S.H., Murray T., Bolden S. , et al. Cancer statistics, 1998 CA Cancer J Clin 1998 ;  48 : 6-29  [cross-ref]

Cliquez ici pour aller à la section Références, 53 Metlin C.J., Murphy G. The national prostate cancer database Cancer 1994 ;  74 : 1640-1648

Cliquez ici pour aller à la section Références</sup> Although research continues to identify new treatment options for this population, the fact remains that most patients will be affected to some degree by pain and other symptoms with a subsequent effect on the quality of life. Health care providers who take care of patients with advanced prostate cancer need to develop strategies in the area of pain and symptom management to care effectively for these patients and improve their quality of life. Current concepts and reports of ongoing research in each of these three areas are the focus of this article.