Molecular nature of granulocyte antigens - 01/01/01
J. Bux * *Correspondence and reprints
Voir les affiliationspages | 6 |
Iconographies | 0 |
Vidéos | 0 |
Autres | 0 |
Résumé |
Granulocyte (neutrophil) antibodies can cause febrile and pulmonary (TRALI) transfusion reactions as well as immune neutropenias. In the last decade enormous efforts have been made to characterize the implicated alloantigens. The NA1, NA2, and SH antigens could be identified as polymorphic forms of the neutrophil FcγReceptor IIIb encoded by three alleles. The antigens MART and OND have been located on the leucocyte adhesion molecules (β2 integrins) and found to be caused by single nucleotide mutations in the αM (CD11b) and αL (CD11a) subunits. We have succeeded in throwing light on the primary structure of the NB1 antigen, which has recently been clustered as CD177. Based on these findings, the Granulocyte Antigen Working Party of the ISBT introduced in 1998 a new nomenclature for human neutrophil alloantigens (HNA nomenclature) based on the antigen's glycoprotein location. Elucidation of the molecular nature of granulocyte antigens now allows antigen identification by glycoprotein-specific immunoassays and genotyping by DNA techniques. Thus, considerable progress has been made in the characterization of granulocyte antigens. Further studies will improve our diagnostic tools and facilitate the prevention and management of transfusion reactions and immune neutropenias.
Mots clés : antigen ; granulocyte ; immune neutropenia ; neutrophil ; transfusion reaction.
Plan
Vol 8 - N° 3
P. 242-247 - juin 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?