Alterations in sleep physiology in young children with insulin-dependent diabetes mellitus: Relationship to nocturnal hypoglycemia - 05/09/11
Abstract |
Objectives: To examine the effect of diabetes per se and nocturnal hypoglycemia on sleep in children with insulin-dependent diabetes mellitus (IDDM). Design: Overnight polysomnography was performed on 3 occasions in 29 children with IDDM - twice during metabolic profiling. Sleep data were analyzed from 14 children (median [range], 8.7 [5.9 to 12.9] years) with a night of hypoglycemia and a nonhypoglycemic night. Seven children in the control group (9 [5.6 to 11.4] years) underwent 2 nights of polysomnography, once during metabolic profiling (to assess the effects of metabolic profiling), and 15 members of the control group had polysomnography only (to assess the effects of diabetes per se and to compare with the index group). Results: Children with IDDM had disrupted sleep compared with the control group (short wakes, percentage of sleep time, 0.8 [0.5 to 1.9] vs 0.0 [0.0 to 0.3], median [interquartile range], IDDM vs control group, respectively, P = .001; long wakes, 1.2 [0.7 to 3.0] vs 0.0 [0.0 to 0.0], P = .033; total number of wakes, 6 [3.5 to 11.5] vs 1 [0 to 2], P = .002). Blood sampling disrupted sleep with increased long wakes as percentage of sleep time (0.3 [0.0 to 3.8] vs 4.3 [3.1 to 16.9], nonsampling vs sampling night, respectively, P = .003). Episodes of hypoglycemia were profound, with a glucose nadir of 2.0 [1.4 to 3.3] mmol/L (35.0 [24.5 to 57.8] mg/dL) and prolonged, 308 [30 to 630] minutes, with no effect on sleep. Conclusions: Children with diabetes had disrupted sleep compared with a control group, but there was no effect of profound nocturnal hypoglycemia on sleep quality. J Pediatr 2000;137:233-8)
Le texte complet de cet article est disponible en PDF.Abbreviations : EEG, IDDM, PSG, SWS
Plan
Dr Matyka was supported initially by Novo Nordisk and by a pediatric diabetes research fellowship from the British Diabetic Association. Dr Wiggs and Ms Crawford were supported by a grant from Novo Nordisk, who also provided funding for the running of the study. |
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Reprint requests: D.B. Dunger, MD, Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom. |
Vol 137 - N° 2
P. 233-238 - août 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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