Sickle-cell disease not identified by newborn screening because of prior transfusion - 05/09/11
Doi : 10.1016/S0022-3476(00)70110-7
William Reed, MD, Peter A. Lane, MD, Fred Lorey, PhD, Jennifer Bojanowski, MS, Michael Glass, MS, Ronald R. Louie, MD, Bertram H. Lubin, MD, Elliott P. Vichinsky, MD
Children’s Hospital Oakland, Department of Hematology/Oncology, Oakland, California; Blood Centers of the Pacific, Irwin Center, San Francisco, California; the Department of Pediatrics and Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine, Denver, Colorado; the Genetic Disease Branch, California Department of Health, Berkeley, California; Washington State Department of Health, Seattle, Washington; Pediatric Hematology/Oncology, Group Health of Puget Sound, Redmond, Washington; and Children’s Hospital Oakland Research Institute, Oakland, California
Abstract |
Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening ≥120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis. (J Pediatr 2000;136:248-50)
Le texte complet de cet article est disponible en PDF.Abbreviations : Hb, NBS, SCD, SS
Plan
 | Supported in part by National Institutes of Health grant HL-20985. |
| Reprint requests: Elliott P. Vichinsky, MD, Director, Hematology/Oncology, Children’s Hospital Oakland, 747 52nd St, Oakland, CA 94609. |
 | 0022-3476/2000/$12.00 + 0 9/22/102617 |
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Vol 136 - N° 2
P. 248-250 - février 2000 Retour au numéro
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