Mechanisms of eosinophil-associated inflammation - 04/09/11
Abstract |
Increasing evidence supports a critical role for the eosinophil in disease. Here, the mechanisms underlying eosinophil-associated inflammation are reviewed including eosinophil constituents, eosinophil maturation and release from the bone marrow, and eosinophil tissue recruitment and activation. Eosinophil effector functions in bronchial asthma are summarized with particular attention to pulmonary M2 muscarinic receptors and bronchial hyperreactivity. Recent findings supporting roles for IL-5, the eosinophil, and its ribonucleases in viral immunity are presented. Overall, this information supports an expanded view of eosinophil participation in health and disease. (J Allergy Clin Immunol 2000;105:651-63.)
Le texte complet de cet article est disponible en PDF.Keywords : Eosinophil, bronchial asthma, IL-5, virus, immunity, localization, ribonuclease
Abbreviations : BAL:, BHR:, CCR3:, ECP:, EDN:, EPO:, HUVEC:, ICAM:, MBP:, MBPH:, MMP:, mRNA:, PAF:, RSV:, sIgA:, TIMP:, VCAM:, VLA:
Plan
![]() | Series editors: Donald Y.M.Leung, MD, PhD, Stanley J. Szefler, MD, and Harold S. Nelson, MD |
![]() ![]() | Supported in part by grants from the National Institutes of Health (No. AI 09728 and AI 34577) and from the Mayo Foundation. |
![]() | Reprints not available from the authors. |
Vol 105 - N° 4
P. 651-663 - avril 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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