Molecular pathology of allergic disease : I: Lower airway disease - 04/09/11
Abstract |
Asthma is a complex disorder associated with eosinophil infiltration and the activation of T lymphocytes within the airways. Recent advances in the pathophysiologic mechanisms of asthma point to the importance of eosinophil-basophil progenitor cells and a family of transcription factors that underlie the development of TH2-type responses. Further research is needed to address the development of chronic inflammatory changes, the role of profibrotic cytokines, and especially their reliance on eosinophils in the lungs. (J Allergy Clin Immunol 2000;105:20-36.)
Le texte complet de cet article est disponible en PDF.Keywords : Bronchial asthma, eosinophils, T lymphocytes, cytokines, chemokines
Abbreviations : AP-1:, BAL:, IL-5R:, LAR:, MBP:, MCP:, MIP-⍺:, MMP:, mRNA:, NF-κB:, TC/S:, TGF-β:, TH:, TIMP:, VCAM-1:
Plan
 | Supported by the Medical Research Council of Canada and the Foulkes Foundation. |
| Reprint requests: Qutayba Hamid, MD, PhD, Meakins-Christie Laboratories, McGill University, 3626 St Urbain, Montreal, PQ H2X 2P2 Canada. |
 | 0091-6749/2000 $12.00 + 0 1/1/104058 |
Vol 105 - N° 1P1
P. 20-36 - janvier 2000 Retour au numéro
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- The environmental predictors of allergic disease
- Erika von Mutius
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