Road signs guiding leukocytes along the inflammation superhighway - 04/09/11
Abstract |
The term inflammation is used to describe the localized tissue changes, including leukocyte extravasation, that occur as part of the response to tissue damage, infection, or other immunologic responses. This carefully orchestrated series of events requires the existence of highly specific, regulated mechanisms for control of leukocyte recruitment and is dependent on both the inciting event and organ involved. This review summarizes recent developments in our understanding of how adhesion molecules and chemokines interact to facilitate tissue-specific and leukocyte subtype–specific influx during inflammation. Novel mechanisms believed to be responsible for capture and compartmentalization of B and T lymphocytes within lymph nodes are discussed, along with a description of adhesion molecule– and chemokine-mediated pathways that are believed to be involved in selective recruitment of lymphocytes and eosinophils to a variety of tissues, including the skin, gut, and lung. This growing knowledge and its potential importance provide enthusiasm for future anti-inflammatory therapies that target these recruitment pathways. (J Allergy Clin Immunol 2000;106:817-28.)
Le texte complet de cet article est disponible en PDF.Keywords : Eosinophils, lymphocytes, homing, recruitment, adhesion molecules, chemokines, skin, gastrointestinal tract, lung, lymph nodes
Abbreviations : BALT, BLC, CLA, CTACK, GALT, HEV, ICAM-1, IP-10, I-TAC, Lex, LFA-1, Mac-1, MAdCAM-1, MCP, MDC, Mig, MIP, plt, PNAd, PSGL-1, SDF, SLC, TARC, TECK, VCAM-1, VLA
Plan
![]() | Supported by a grant from Merck & Co, Inc, West Point, Pa |
![]() ![]() | Supported by grants No. AI41472 and AI45115 from the National Institutes of Health. |
![]() | Reprint requests: Bruce S. Bochner, MD, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224-6801. |
Vol 106 - N° 5
P. 817-828 - novembre 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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