Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: A randomized crossover study - 04/09/11
, Yuta Kono, Yuhki Togashi, Shinya Sugiyama, Motochika Tanakadate, Seiko Soeda, Michiko Nakai, Norihiro Sugiyama, Akahito Fujiwara, Kouichi Yamaguchi, Aya Yamaguchi, Nao Kurita
Corresponding author. Tel.: +81 3 3342 6111; fax: +81 3 5381 6651.Abstract |
Background |
The addition of transdermal tulobuterol (Tulo) to inhaled tiotropium bromide (Tio) produced beneficial effects on spirometry-assessed parameters of respiratory function, disease-related symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD).
Aim |
To compare the effects of Tio plus Tulo versus Tio alone on peripheral airway obstruction and quality of life in Japanese patients with COPD using impulse oscillation system (IOS)-assessed measures.
Patients and methods |
Patients aged 50–80 years with clinically stable COPD and a forced expiratory volume in 1 s (FEV1) that was 30–80% of the predicted value were randomized to receive Tio 18 μg once daily, or combination therapy with Tio 18 μg once daily plus Tulo 2 mg once daily for 4 weeks. Patients then switched treatments for a further 4 weeks.
Results |
Sixteen patients completed the study. Tio plus Tulo was associated with significantly greater improvements than Tio in IOS-assessed markers of resistance (R5 and R5–R20), reactance and reactance area, from baseline to week 4. Both treatments significantly improved these markers over the 4-week treatment period, with the exception of R20 for which improvements were not significant. Tio plus Tulo improved symptoms of dyspnea to a significantly greater extent than Tio alone. St. George’s Respiratory Questionnaire Score–Total was not significantly different between the two groups, but improvement from baseline in the ‘impact’ component was significantly greater with Tio plus Tulo than with Tio alone.
Conclusions |
Coadministration of transdermal Tulo with inhaled Tio, as well as Tio alone, is associated with beneficial effects on IOS-assessed measures of peripheral airway obstruction in patients with COPD.
Le texte complet de cet article est disponible en PDF.Résumé |
Highlights |
► Inhaled Tio improved impulse oscillatory system parameters in COPD patients. ► Tio + Tulo produced better improvements in peripheral airway function than Tio alone. ► Spirometry-assessed parameters improved significantly and similarly in both groups. ► Tio + Tulo and Tio alone improved quality of life. ► Impulse oscillometry can detect pathological changes in peripheral airway function.
Le texte complet de cet article est disponible en PDF.Keywords : COPD, Transdermal, Tulobuterol, Tiotropium bromide, Impulse oscillation system
Plan
Vol 24 - N° 5
P. 617-624 - octobre 2011 Retour au numéro
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