The association of HLA class II with pars planitis - 03/09/11
Abstract |
PURPOSE: To investigate the association of HLA class II alleles with pars planitis.
METHODS: Blood samples were obtained from 28 patients with pars planitis seen in the Department of Ophthalmology and Visual Sciences and the Barnes Retina Institute at Washington University, St. Louis, Missouri.
RESULTS: HLA-DR15, one of the allelic subtypes of HLA-DR2, was present in 18 (64.3%) of 28 patients vs. 10 (20%) of 50 controls (OR = 7.20, CI = 2.28–23.20, P = .0001). HLA-DR51 (HLA-DRB 5) was present in 16 (57.1%) of 28 patients vs. 6 (12%) of 50 controls (OR = 9.78, CI = 2.79–36.42, P = .0001). HLA-DR17 was present in eight (28.6%) of 28 patients vs. one (2%) of 50 controls (OR = 19.60, CI = 2.29–886.7, P = .0001).
CONCLUSION: Pars planitis is associated with an increased frequency of the HLA-DR2 suballele, -DR15, HLA-DR51, and HLA-DR17. These results suggest an immunogenic predisposition exists to pars planitis.
Le texte complet de cet article est disponible en PDF.| ☆ | Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, and Grant EY09730 from the National Institutes of Health, Bethesda, Maryland. |
Vol 131 - N° 5
P. 657-659 - mai 2001 Retour au numéro
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